Cells in population or multicellular organisms possess a phenomenon in which they lose their vigor. Why is this cell vigor-loss mechanism conserved in multicellular organisms? During development, a large amount of programmed cell death occurs, playing a crucial role in processes such as morphogen switching, morphogenetic movements, and the elimination of cells that have failed to differentiate. In adults, cell competition functions as a tumor suppression mechanism by removing precancerous cells. Additionally, maintaining stem cells involves inducing selective cell death to preserve their quality. Organisms have a maximum lifespan beyond which they cannot survive. Although aging has been evolutionarily conserved, our understanding of its biological role is still limited.

In addition to cell death and organismal death, cells, and organisms have developed various responses to cope with environmental changes and stress, which can lead to a decline in vigor. In extreme cases, they reduce their overall metabolism and enter states such as dormancy or hibernation.

The aim of this conference is to discuss how the regulation of cell vigor influences phenotypes at the level of cell populations and organisms, drawing on research in areas such as cell death, control of cell fate, stem cells, cellular stress responses, aging, and hibernation.

Approaches to researching cell vigor span a wide range of fields, including live imaging, genetics, molecular biology, biochemistry, and metabolism. In order to deepen our understanding of the mechanisms underlying the regulation of cell vigor, we look forward to research exchanges across the hierarchy of technologies and research subjects in order to understand the mechanisms of cell vigor.

Invited Speakers:

Ulrich Brinkmann (Roche Innovation Center Munich, Penzberg, Germany) Online presentation

Tatsushi Igaki (Kyoto University, Japan)

Akiko Koto (National Institute of Advanced Industrial Science and Technology, Japan)

Sharad Kumar (University of South Australia, Australia)

Kyoko Miura (Kyushu University, Japan)

Atsushi Miyawaki (RIKEN Center for Brain Science, Japan)

Hozumi Motohashi (Tohoku University, Japan)

Shigekazu Nagata (Osaka University, Japan)

Yasushi Okada (The University of Tokyo / RIKEN Center for Biosystems Dynamics Research, Japan)

Natsuki Shinoda (The University of Tokyo, Japan)

Yusuke Toyama (National University of Singapore, Singapore)

Yuichi Wakamoto (The University of Tokyo, Japan)

Benjamin Weaver (The University of Texas Southwestern Medical Center, USA)

Yoshifumi Yamaguchi (Hokkaido University, Japan)

Shosei Yoshida (National Institute for Basic Biology, Japan)

Junying Yuan (Chinese Academy of Sciences, China)

Day 1: 2025.11.6 (Thu)

12:00 - 13:00   Registration

13:00 - 13:05 Opening Remarks

Masayuki Miura (National Institute for Basic Biology, JP)

Session 1 Chair: Masayuki Miura (National Institute for Basic Biology, JP)

13:05 - 13:50 Keynote Talk 1

Dissecting Key Mechanisms of Aging by Chemical Biology

Junying Yuan (Chinese Academy of Sciences, CN)

13:50 - 14:20 Caspase-Mediated Regulation of Stress Responses

Benjamin Weaver (The University of Texas Southwestern Medical Center, US)

14:20 - 14:50 Regulating Cell Survival and Death via Ubiquitination

Sharad Kumar (University of South Australia, AU)

14:50 - 15:10 Coffee break

Session 2 Chair: Hirotaka Kanuka (Jikei University School of Medicine, JP)

15:10 - 15:40 Supersulfides as Emerging Biomolecules for Stress Repsonse

Hozumi Motohashi (Tohoku University, JP)

15:40 - 16:10 Elucidating the Molecular Basis of the Healthy Aging System in the Longest-lived Rodent, the Naked Mole-rat

Kyoko Miura (Kyushu University, JP)

16:10 - 16:40 Finding Genetic Clues to the Mystery of Mammalian Hibernation

Yoshifumi Yamaguchi (Hokkaido University, JP)

16:40 - 17:10 The Influence of Social Environment on Health and Longevity in Ants

Akiko Koto (National Institute of Advanced Industrial Science and Technology, JP)

17:10 - 17:30 Coffee break

Session 3 Chair: Masayuki Miura (National Institute for Basic Biology, JP)

17:30 - 18:00 Diphthamide: a conserved modification of eEF2 with clinical relevance

Ulrich Brinkmann (Roche Innovation Center Munich, Penzberg, DE) 

    Online talk

18:00 - 18:30 Cruising inside cells

Atsushi Miyawaki (RIKEN Center for Brain Science, JP)

18:30 - 20:30 Mixer dinner

Day 2: 2025.11.7 (Fri)                                  

Session 4 Chair: Katsumori Segawa (Institute of Science Tokyo, JP)

Masayuki Miura (National Institute for Basic Biology, JP)

9:00-9:45 Keynote Talk 2

Flippases and Scramblases, and Their Defects

Shigekazu Nagata (Osaka University, JP)

9:45-10:15 Early-Peaking Caspase-7 Activity at the Plasma Membrane Drives Apoptotic Phosphatidylserine Exposure

Natsuki Shinoda (The University of Tokyo, JP)

10:15-10:45 Cell Non-autonomous Clearance of Senescence Cells within Aging Tissue

Yusuke Toyama (National University of Singapore, SG)

10:45-11:00 Coffee break

Session 5 Chair: Toshihiko Fujimori (National Institute for Basic Biology, JP)

11:00-11:30 Mechanisms that Determine Cellular Fitness

Tatsushi Igaki (Kyoto University, JP)

11:30-12:00 TBA

Yasushi Okada (The University of Tokyo / RIKEN Center for Biosystems Dynamics Research, JP)

12:00-12:30 Non-genetic Enhancement of Antibiotic Resistance

Yuichi Wakamoto (The University of Tokyo, JP)

12:30-13:00 Self-Organization of the Spermatogenic Wave Sustains Sperm Production

Shosei Yoshida (National Institute for Basic Biology, JP)

13:00-13:10 Group Photo

13:10-14:35 Lunch along with Poster session

13:15-13:55 Odd Numbers

13:55-14:35 Even Numbers

Session for Short talks Chair: Shosei Yoshida (National Institute for Basic Biology, JP)

14:40-14:55 Short talk 1

TBA

14:55-15:10 Short talk 2

TBA

15:10-15:25 Short talk 3

TBA

15:25-15:40 Short talk 4

TBA

15:40-15:45 Closing Remarks

Toshihiko Fujimori (National Institute for Basic Biology, JP)

Invited Speakers and those who wish to attend will be required to register via the following links.

Registration Form ← Click here! (powered by Google Form)

Registration deadline: October 6th, 2025

We encourage participants to consider giving a poster presentation.

Several opportunities for short talks will be offered, based on poster submissions.

※ Privacy Policy and Confidentiality for the 69th NIBB Conference

Abstract submission:

1. Download an abstract template file from here.

2. Email it to the conference office (nibbconf@nibb.ac.jp). 

Abstract submission deadline: September 30th, 2025　→　October 6th, 2025

Information on meals during the conference:

During the period of the conference, we will serve meals for all participants.

1 mixer dinner on November 6th and 1 lunch on Novermber 7th will be served.

Information about poster presentation: 

The poster session is scheduled for November 7th, coinciding with lunch. 

The short talk session will take place on the afternoon of the same day. 

Further details will be announced later.

Organizers:

Masayuki Miura (National Institute for Basic Biology, Japan)

Toshihiko Fujimori (National Institute for Basic Biology, Japan)

Co-Organizer:

Kiyoshi Tatematsu (National Institute for Basic Biology, Japan)

How to access

Accommodation list